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Research Reference · Tissue Repair & Skin Blend

KLOW (Four-Peptide Blend)

A four-peptide research blend — GHK-Cu, TB-500, BPC-157 and KPV — combining collagen, cell-migration, repair and anti-inflammatory research in one vial.

Last reviewed September 2026 8 peer-reviewed sources 3-minute read

At a glance

KLOW is a four-peptide research blend: GHK-Cu (50 mg) with TB-500, BPC-157 and KPV at 10 mg each — 80 mg in total. It is GLOW plus KPV, a three-amino-acid peptide (Lys-Pro-Val) from the hormone α-MSH that reduced inflammation in colitis models. No study of the blend itself has been published; the evidence belongs to the components.

TypeFour-peptide blend (80 mg)
ComponentsGHK-Cu 50 · TB-500, BPC-157, KPV 10 mg
Evidence stageComponent studies (preclinical)
Human dataNone for the blend

What it’s studied for

Collagen & skin matrix

GHK-Cu stimulated collagen synthesis in fibroblast cultures. 2,1

Cell

Repair signaling

BPC-157 is studied across wound and tendon repair models. 3,4

Cell & animal

Cell migration

Thymosin beta-4 controls actin, the protein cells use to move. 5

Cell

Inflammation (KPV)

KPV enters gut and immune cells via PepT1 and reduced inflammation in mouse colitis. 6,7,8

Animal

KLOW

KLOW (80mg) · $119.99

Third-party tested · batch-matched COA · research use only

View KLOW KLOW COAsUsage guide

How it works

KLOW combines four peptides with different mechanisms. GHK-Cu — the largest share of the vial — stimulated collagen synthesis in fibroblasts and is linked to repair genes in gene-data work. 2,1 BPC-157 is studied for repair signaling in wound and tendon models, 3,4 and TB-500 (thymosin beta-4) controls actin, which cells use to move. 5

The fourth component, KPV, is the three-amino-acid tail of the hormone α-MSH (Lys-Pro-Val). It is carried into gut and immune cells by the PepT1 transporter, and given orally it reduced colitis in mice. 6 In a second study it rescued mice from death in a colitis model, partly independent of the MC1R receptor. 7 Reviews discuss it with α-MSH as an anti-inflammatory peptide. 8

No study of the combined blend has been published, so each component’s evidence should be read on its own terms.

Related research

GLOW (Three-Peptide Blend)KLOW without KPV GHK-Cu (Copper Peptide)Largest component BB (BPC-157 & TB-500)BPC-157 + TB-500 BPC-157Component

Frequently asked questions

What is in KLOW?
GHK-Cu (50 mg), TB-500 (10 mg), BPC-157 (10 mg) and KPV (10 mg) in one vial — 80 mg of total peptide.
What is KPV?
A tripeptide, Lys-Pro-Val, from the C-terminal end of the hormone α-MSH, studied for anti-inflammatory effects in colitis models.
How is KLOW different from GLOW?
KLOW is GLOW plus KPV.
Has the KLOW blend itself been studied?
No published study tests the blend. The research belongs to each component.
How is each batch verified?
The batch certificate of analysis measures all four components separately and is published on our COA page.

Identifiers

Components GHK-Cu (50 mg) + TB-500 (10 mg) + BPC-157 (10 mg) + KPV (10 mg)
Total peptide 80 mg per vial
GHK-Cu C14H23CuN6O4 · CAS 89030-95-5 · PubChem CID 71587328
BPC-157 C62H98N16O22 · CAS 137525-51-0 · PubChem CID 9941957
KPV Lys-Pro-Val (α-MSH 11–13) · C16H30N4O4 · CAS 67727-97-3 · PubChem CID 125672
TB-500 Thymosin beta-4 / its 17–23 fragment — see the TB-500 page
Supplied as Lyophilized (freeze-dried) powder

Component identifiers checked against PubChem.

Research timeline

  1. 1988GHK-Cu stimulates collagen synthesis in fibroblasts. 2
  2. 2008KPV reduces intestinal inflammation via PepT1 6 and in two mouse colitis models 7; review of α-MSH-related tripeptides. 8
  3. 2011BPC-157 increases tendon-cell outgrowth, survival and migration. 4
  4. 2018Review links GHK-Cu’s actions to gene data. 1
  5. 2021Reviews of BPC-157 in wound healing 3 and of thymosin beta-4. 5

Key studies

StudyModelWhat it found
Maquart 1988 2 Cell (GHK-Cu) Collagen synthesis stimulated at nanomolar concentrations.
Chang 2011 4 Cell (BPC-157) More tendon-cell outgrowth, survival and migration.
Dalmasso 2008 6 Cell + mouse (KPV) Taken up via PepT1; oral KPV reduced DSS- and TNBS-induced colitis.
Kannengiesser 2008 7 Mouse (KPV) Significant anti-inflammatory effects in two colitis models.

Sources

  1. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Pickart L, Margolina A. Int J Mol Sci, 2018. Free full textReview
  2. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Maquart FX, et al. FEBS Lett, 1988.
  3. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Seiwerth S, et al. Front Pharmacol, 2021. Free full textReview
  4. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Chang CH, et al. J Appl Physiol, 2011.
  5. Progress on the Function and Application of Thymosin β4. Xing Y, et al. Front Endocrinol (Lausanne), 2021. Free full textReview
  6. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Dalmasso G, et al. Gastroenterology, 2008. Free full text
  7. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Kannengiesser K, et al. Inflamm Bowel Dis, 2008.
  8. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Brzoska T, et al. Endocr Rev, 2008. Review
For Research Use Only. This page summarizes published scientific research for educational purposes. It is not medical advice and does not promote, recommend, or describe any human or animal use. Products referenced are sold strictly for laboratory research and are not for human consumption.

Last reviewed September 2026 by Midwest Compounds. Every source above was checked against its original publication.